Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Tal1-cre/ERT)1Jrg
Name:	transgene insertion 1, Joachim R Gothert
MGI ID:	MGI:3055721
Synonyms:	end-SCL-Cre-ERT, SCL-Cre-ERT
Transgene:	Tg(Tal1-cre/ERT)1Jrg  Location: unknown
Alliance:	Tg(Tal1-cre/ERT)1Jrg page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Tal1-cre/ERT)1Jrg expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Tal1   Mutation details: The transgene is composed of the 5' Tal1 enhancer element (from -7 to -0.9 kb relative to the transcription start site in exon 1a), the SV40 minimal promoter, and the Cre-ERT cassette, including a rabbit Beta-globin intron. The enhancer element drove the endothelial-specific expression of the transgene. Cre was active in the presence of tamoxifen. (J:92965)

Activity:	Tissue activity of this recombinase allele
Driver:	Tal1 (species not specified) Summary of all recombinase alleles driven by Tal1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(Tal1-cre/ERT)1Jrg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:92965 Gothert JR, et al., Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood. 2004 Sep 15;104(6):1769-77
All:	45 reference(s)