Mapk1<tm1Moga> Targeted Allele Detail MGI Mouse (MGI:3055889)

Mapk1^tm1Moga
Targeted Allele Detail

Summary

Symbol:	Mapk1^tm1Moga
Name:	mitogen-activated protein kinase 1; targeted mutation 1, Masato Ogata
MGI ID:	MGI:3055889
Synonyms:	Erk2^floxS
Gene:	Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
Alliance:	Mapk1^tm1Moga page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:89903
Parent Cell Line:	EB3/5 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeting vector was used to insert a floxed region containing a splice acceptor, IRES, neo and SV40 pA into intron 2. Mapk1 cDNA with a polyA tail was inserted in place of exon 3. Protein was undetectable by immunoblot analysis. (J:89903)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:	43 strains or lines available

Notes

ES cell line EB3/5 is a mutant E14TG2a line carrying one inactivated allele of Pou5f1.
Rescue of placental defects by complementation with tetraploid embryos extends survival up to at least E13.5. These rescued mutant mice have a normal heart, exhibit normal placental development and grow as well as wild-type embryos.

References

Original:	J:89903 Hatano N, et al., Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells. 2003 Nov;8(11):847-56
All:	3 reference(s)

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