Pkp2tm1Wbm
Targeted Allele Detail
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| Symbol: |
Pkp2tm1Wbm |
| Name: |
plakophilin 2; targeted mutation 1, Walter Birchmeier |
| MGI ID: |
MGI:3487374 |
| Gene: |
Pkp2 Location: Chr16:16031209-16090576 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
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| Alliance: |
Pkp2tm1Wbm page
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E10.75 Pkp2tm1Wbm/Pkp2tm1Wbm embryos accumulate blood in pericardial and peritoneal cavities and lack red blood cells in the yolk sac vasculature
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:93314
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 7.8 kb genomic fragment within exon 1 and intron 1 was replaced by a neomycin selection cassette in opposite transcriptional orientation to the gene via homologous recombination, creating a stop codon after 43 aa. Western blot with an antibody against the COOH terminus and immunofluorescence analysis confirmed the absence of protein in E10.75 embryos and cardiac tissue, respectively.
(J:93314)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pkp2 Mutation: |
40 strains or lines available
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| Original: |
J:93314 Grossmann KS, et al., Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 2004 Nov 11;167(1):149-60 |
| All: |
7 reference(s) |
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Analysis Tools
