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Cdsn Gene Detail
Summary
  • Symbol
    Cdsn
  • Name
    corneodesmosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:3505689
    NCBI Gene: 386463
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35863025-35868077 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3505689
 protein coding gene Chr17:35854044-35868077 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023644
 protein coding gene Chr17:35723669-35731336 (+)
A/J MGP_AJ_G0023599
 protein coding gene Chr17:34624471-34629491 (+)
AKR/J MGP_AKRJ_G0023569
 protein coding gene Chr17:35029897-35034947 (+)
BALB/cJ MGP_BALBcJ_G0023604
 protein coding gene Chr17:34756016-34761095 (+)
C3H/HeJ MGP_C3HHeJ_G0023370
 protein coding gene Chr17:35496643-35501693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024046
 protein coding gene Chr17:37185589-37191720 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021524
 protein coding gene Chr17:32324353-32329509 (+)
CAST/EiJ MGP_CASTEiJ_G0022861
 protein coding gene Chr17:35603651-35609193 (+)
CBA/J MGP_CBAJ_G0023348
 protein coding gene Chr17:38729357-38734406 (+)
DBA/2J MGP_DBA2J_G0023472
 protein coding gene Chr17:33937104-33942163 (+)
FVB/NJ MGP_FVBNJ_G0023443
 protein coding gene Chr17:33729376-33734420 (+)
LP/J MGP_LPJ_G0023552
 protein coding gene Chr17:36112898-36118432 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023464
 protein coding gene Chr17:37544629-37549674 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024089
 protein coding gene Chr17:35362921-35368437 (+)
PWK/PhJ MGP_PWKPhJ_G0022612
 protein coding gene Chr17:32791779-32797417 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022431
 protein coding gene Chr17:33401469-33408756 (+)
WSB/EiJ MGP_WSBEiJ_G0022927
 protein coding gene Chr17:35498287-35505023 (+)



Homology
more
  • Human Ortholog
    CDSN, corneodesmosin
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDSN, corneodesmosin
  • Synonyms
    HTSS, HTSS1, HYPT2, PSS, PSS1
  • Links
    NCBI Gene ID: 1041
    neXtProt AC: NX_Q15517
    UniProt: Q15517

  • Chr Location
    6p21.33; chr6:31115087-31120446 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CDSN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    6 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display neonatal lethality with epidermal detachment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    8
  • cDNA Data
    5
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039518 Ensembl Gene Model | MGI Sequence Detail 5053 C57BL/6J ±  kb
    transcript ENSMUST00000044804 Ensembl | MGI Sequence Detail 2678 Not Applicable  
    polypeptide ENSMUSP00000048596 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146920
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:93050 Yang T, et al., Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 1;18(19):2354-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory