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Ntrk1tm1Tes
Targeted Allele Detail
Summary
Symbol: Ntrk1tm1Tes
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Lino Tessarollo
MGI ID: MGI:3505767
Synonyms: TrkA-, TrkAneo
Gene: Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Alliance: Ntrk1tm1Tes page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93578
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A floxed PGK-neopA was inserted into intron 11. Northern blot and RT-PCR indicated a lack of transcript in dorsal root ganglia of mutants. Upon cre-mediated recombination, expression of the gene is restored. (J:93578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  62 strains or lines available
References
Original:  J:93578 Coppola V, et al., Ablation of TrkA function in the immune system causes B cell abnormalities. Development. 2004 Oct;131(20):5185-95
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory