Traf3ip2<tm1.1Lix> Targeted Allele Detail MGI Mouse (MGI:3510784)

Traf3ip2^tm1.1Lix
Targeted Allele Detail

Summary

Symbol:	Traf3ip2^tm1.1Lix
Name:	TRAF3 interacting protein 2; targeted mutation 1.1, Xiaoxia Li
MGI ID:	MGI:3510784
Synonyms:	Act1^-
Gene:	Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
Alliance:	Traf3ip2^tm1.1Lix page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:93923
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Act1^tm1Lix ES cells were transfected with Cre recombinase to remove the floxed neo and exon 2. RNA blot indicated the absence of transcript in splenic B cells. (J:93923)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Traf3ip2 Mutation:	41 strains or lines available

References

Original:	J:93923 Qian Y, et al., Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004 Oct;21(4):575-87
All:	17 reference(s)

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