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Chrna4tm2Lst
Targeted Allele Detail
Summary
Symbol: Chrna4tm2Lst
Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 2, Henry A Lester
MGI ID: MGI:3511287
Synonyms: L9'A, Leu9'Ala
Gene: Chrna4  Location: Chr2:180664104-180685339 bp, - strand  Genetic Position: Chr2, 103.54 cM
Alliance: Chrna4tm2Lst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93873
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation details: A point mutation was introduced to change a leucine to alanine within the putative pore-forming M2 domain. A loxP flanked neo cassette was also inserted in the construct. Correctly targeted ES cells were transfected with Cre plasmid to remove the neo. (J:93873)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chrna4 Mutation:  44 strains or lines available
References
Original:  J:93873 Tapper AR, et al., Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science. 2004 Nov 5;306(5698):1029-32
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory