Myh9Gt(Betageo-btk)1Dash
Gene trapped Allele Detail
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| Symbol: |
Myh9Gt(Betageo-btk)1Dash |
| Name: |
myosin, heavy polypeptide 9, non-muscle; gene trap 1, Tadashi Matsushita |
| MGI ID: |
MGI:3511350 |
| Synonyms: |
MYH9- |
| Gene: |
Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
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| Alliance: |
Myh9Gt(Betageo-btk)1Dash page
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| Mutant Cell Line: |
OST208974 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:94067
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| Parent Cell Line: |
Lex-1 (ES Cell)
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| Strain of Origin: |
129S5/SvEvBrd
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
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Mutation details: A gene trap vector containing a splice acceptor sequence, promotorless Betageo, pA, PGK, exon 1 from Btk and splice donor sequence, was inserted into intron 1 of the endogenous gene. Btk contained a stop codon in each reading frame to prevent translation of downstream fusion transcripts. Protein expression was reduced by half in heterozygotes as shown by immonoblot analysis.
(J:94067)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
279 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Myh9 Mutation: |
219 strains or lines available
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| Original: |
J:94067 Matsushita T, et al., Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1163-71 |
| All: |
2 reference(s) |
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Analysis Tools
