Myo7a<Hdb> Chemically induced Allele Detail MGI Mouse (MGI:3511858)

Myo7a^Hdb
Chemically induced Allele Detail

Summary

Symbol:	Myo7a^Hdb
Name:	myosin VIIA; headbanger
MGI ID:	MGI:3511858
Synonyms:	ABE6
Gene:	Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
Alliance:	Myo7a^Hdb page

Stereocilia defects in Myo7a^Hdb/Myo7a⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C3HeB/FeJ

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: An A to T transversion at position 531 in exon 6 of Myo7a was identified and is predicted to cause an isoleucine-to-phenylalanine amino acid substitution at position 178, however no evidence of complementation was found when homozygotes were mated with heterozygous Myo7a^4626SB. (J:93998)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Myo7a Mutation:	118 strains or lines available

References

Original:	J:93998 Rhodes CR, et al., A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mamm Genome. 2004 Sep;15(9):686-97
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24