Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ts(1716)65Dn Name: trisomy, Chr 16 translocation to Chr 17, Davisson 65 MGI ID: MGI:3512067 Synonyms: T(16C3-4;17A2)65Dn, Ts16, Ts65Dn Gene: Ts(1716)65Dn  Location: unknown  Genetic Position: Chr16, Syntenic

Cardiovascular abnormalities in Ts(1716)65Dn/0 mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

DBA/2J

Allele Type:    Radiation induced Mutation:    Translocation   Ts(1716)65Dn involves 140 genes/genome features (Gm21833, Ncam2, 7120432I05Rik ...) View all   Mutation details: About 15% of the distal end of chromosome 16 (about 13.4 Mb; between Ncam2 (81,624,530 bp; NCBI37/mm9) and Mrpl39 (84,718,526; NCBI37/mm9)) is fused to less than 10% of the centromeric end of chromosome 17 (about 5 to 10 Mb; between RP23-147G23, Synj2 (5,988,977 bp; NCBI37/mm9) and D17Mit58 (10,489,635 bp; NCBI37/mm9)) to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031, J:178871)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	28 assay results 10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

List all tumor models in MMHCdb carrying Ts(1716)65Dn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ts(1716)65Dn Mutation:	2 strains or lines available

Original:	J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
All:	348 reference(s)