Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ts(1716)65Dn Name: trisomy, Chr 16 translocation to Chr 17, Davisson 65 MGI ID: MGI:3512067 Synonyms: T(16C3-4;17A2)65Dn, Ts16, Ts65Dn Gene: Ts(1716)65Dn  Location: unknown  Genetic Position: Chr16, Syntenic

Cardiovascular abnormalities in Ts(1716)65Dn/0 mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

DBA/2J

Allele Type:    Radiation induced Mutation:    Translocation   Ts(1716)65Dn involves 140 genes/genome features (Gm21833, Ncam2, 7120432I05Rik ...) View all   Mutation details: About 15% of the distal end of chromosome 16 (about 13.4 Mb; between Ncam2 (81,624,530 bp; NCBI37/mm9) and Mrpl39 (84,718,526; NCBI37/mm9)) is fused to less than 10% of the centromeric end of chromosome 17 (about 5 to 10 Mb; between RP23-147G23, Synj2 (5,988,977 bp; NCBI37/mm9) and D17Mit58 (10,489,635 bp; NCBI37/mm9)) to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031, J:178871)

Key:	hm homozygous ht heterozygous tg involves transgenes √ phenotype observed cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/ Background:	Allelic Composition Genetic Background Cell Line(s) Allelic Composition Genetic Background Cell Line(s) Loading... cx1 Rcan1tm1Fmc/Rcan1+ Ts(1716)65Dn/0 involves: 129S4/SvJae * C3H/HeSn * C57BL/6 * C57BL/6Ei * DBA/2J   cx2 Ts(1716)65Dn/Del(16Cbr1-Fam3b)1Rhr involves: 129S6/SvEvTac * C57BL/6 * DBA/2J   cx3 Del(16App-Runx1)5Yah/Ts(1716)65Dn involves: BALB/c * C3H * C57BL/6 * DBA/2J   ot4  Disease Model Ts(1716)65Dn/0 B6EiC3Sn a/A-Ts(1716)65Dn/J   ot5  Disease Model Ts(1716)65Dn/0 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ   ot6  Disease Model Ts(1716)65Dn/0 involves: BALB/c * C3H/He * C57BL/6JEiJ * DBA/2J   ot7 Ts(1716)65Dn/0 involves: C3H * C57BL/6 * DBA/2J   ot8 Ts(1716)65Dn/0 involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J   ot9 Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6 * DBA/2J   ot10  Disease Model Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6J * DBA/2J   ot11 Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6JEi * DBA/2J   ot12  Disease Model Ts(1716)65Dn/0 involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J   ot13 Ts(1716)65Dn/0 involves: DBA/2J
Phenotypes:	Affected Systems cx1 cx2 cx3 ot4 ot5 ot6 ot7 ot8 ot9 ot10 ot11 ot12 ot13 show or hide all annotated terms Sex:                         behavior/neurological N √ √ √ √ behavior/neurological phenotype N abnormal learning/memory/conditioning √ √ impaired contextual conditioning behavior √ √ √ impaired cued conditioning behavior √ √ abnormal spatial learning √ √ √ impaired spatial learning √ abnormal spatial working memory √ increased thigmotaxis √ abnormal response to novel object √ decreased grip strength √ √ hyperactivity √ √ √ increased vertical activity √ √ √ increased stereotypic behavior √ √ abnormal nest building behavior √ cardiovascular system √ √ retroesophageal right subclavian artery √ abnormal heart morphology √ ventricular septal defect √ decreased heart rate √ abnormal heart electrocardiography waveform feature √ √ prolonged RR interval √ prolonged PR interval √ decreased P wave amplitude √ abnormal QRS complex √ decreased QRS amplitude √ prolonged QRS complex duration √ prolonged QT interval √ cellular √ √ abnormal male germ cell morphology √ oligozoospermia √ √ arrest of male meiosis √ decreased sperm progressive motility √ asthenozoospermia √ craniofacial √ √ √ √ abnormal craniofacial morphology √ decreased cranium height √ small cranium √ √ enlarged neurocranium √ abnormal incisor morphology √ abnormal mandibular angle morphology √ small mandibular coronoid process √ small mandible √ √ endocrine/exocrine glands √ abnormal testis morphology √ abnormal Sertoli cell morphology √ decreased testis weight √ growth/size/body √ √ √ √ √ √ abnormal incisor morphology √ decreased body size √ √ decreased body weight √ √ √ √ √ decreased body length √ √ hematopoietic system √ abnormal spleen red pulp morphology √ abnormal spleen B cell follicle morphology √ abnormal spleen B cell follicle shape √ increased spleen B cell follicle size √ immune system √ abnormal spleen red pulp morphology √ abnormal spleen B cell follicle morphology √ abnormal spleen B cell follicle shape √ increased spleen B cell follicle size √ limbs/digits/tail √ short femur √ mortality/aging N √ mortality/aging N postnatal lethality, incomplete penetrance √ neoplasm √ √ √ decreased tumor growth/size √ √ increased lymphoma incidence √ increased follicular lymphoma incidence √ increased malignant tumor incidence √ nervous system √ √ √ √ √ √ abnormal brain morphology √ increased brain size √ abnormal hippocampus morphology √ abnormal dentate gyrus morphology √ abnormal hippocampus granule cell layer √ abnormal cerebellar granule cell morphology √ √ √ small cerebellum √ abnormal nervous system development √ abnormal CNS synapse formation √ √ abnormal neuron morphology √ √ abnormal Purkinje cell morphology √ decreased Purkinje cell number √ abnormal dendrite morphology √ √ reproductive system √ √ abnormal male germ cell morphology √ decreased sperm progressive motility √ asthenozoospermia √ abnormal testis morphology √ abnormal Sertoli cell morphology √ decreased testis weight √ abnormal spermatogenesis √ oligozoospermia √ √ arrest of male meiosis √ male infertility √ reduced male fertility √ skeleton √ √ √ decreased cranium height √ small cranium √ √ enlarged neurocranium √ abnormal incisor morphology √ abnormal mandibular angle morphology √ small mandibular coronoid process √ small mandible √ √ short femur √

View phenotypes and curated references for all genotypes (concatenated display).

Key:	√ disease model   expected model not found
Models:	Human Diseases ot4 ot5 ot6 ot10 ot12 Down syndrome IDs Down syndrome       DOID:14250 ICD10CM:Q90 ICD9CM:758.0 MESH:D004314 NCI:C2993 OMIM:190685 ORDO:870 UMLS_CUI:C0013080 Close √ √ √ √ √

In Mice Carrying this Mutation:	28 assay results 10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

List all tumor models in MMHCdb carrying Ts(1716)65Dn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ts(1716)65Dn Mutation:	2 strains or lines available

Original:	J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
All:	348 reference(s)