Aldh1a3<tm1Gdu> Targeted Allele Detail MGI Mouse (MGI:3512079)

Aldh1a3^tm1Gdu
Targeted Allele Detail

Summary

Symbol:	Aldh1a3^tm1Gdu
Name:	aldehyde dehydrogenase family 1, subfamily A3; targeted mutation 1, Gregg Duester
MGI ID:	MGI:3512079
Synonyms:	Raldh3^-
Gene:	Aldh1a3 Location: Chr7:66040640-66077225 bp, - strand Genetic Position: Chr7, 35.73 cM, cytoband C
Alliance:	Aldh1a3^tm1Gdu page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:108515
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exon 11 was removed via cre mediated recombination. Retinoic acid activity was absent from the ventral retina and olfactory pit at E10.5. (J:108515)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Aldh1a3 Mutation:	26 strains or lines available

References

Original:	J:108515 Molotkov A, et al., Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. Development. 2006 May;133(10):1901-10
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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