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Txnrd2tm1.1Marc
Targeted Allele Detail
Summary
Symbol: Txnrd2tm1.1Marc
Name: thioredoxin reductase 2; targeted mutation 1.1, Marcus Conrad
MGI ID: MGI:3512409
Synonyms: TrxR2-
Gene: Txnrd2  Location: Chr16:18245167-18297823 bp, + strand  Genetic Position: Chr16, 11.41 cM
Alliance: Txnrd2tm1.1Marc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94136
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: Crossing to a cre-deleter strain resulted in excision the 4 floxed exons containing the C-terminal catalytic center. Low levels of a truncated message were detected by RT-PCR (J:94136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnrd2 Mutation:  18 strains or lines available
References
Original:  J:94136 Conrad M, et al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov;24(21):9414-23
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory