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Mapttm1(cre)Nagy
Targeted Allele Detail
Summary
Symbol: Mapttm1(cre)Nagy
Name: microtubule-associated protein tau; targeted mutation 1, Andras Nagy
MGI ID: MGI:3512756
Synonyms: Tau::Cre
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance: Mapttm1(cre)Nagy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94203
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mapttm1(cre)Nagy expression driven by 1 gene
 
Mutation details: An NLS-Cre-PGK-neo cassette was inserted into exon one, deleting most of the exon 1 coding sequence of the endogenous gene, shifting the start codon site 3 bp downstream and placing it in a partially optimized KOZAK consensus sequence. (J:94203)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mapt (mouse)
Summary of all recombinase alleles driven by Mapt.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  430 strains or lines available
References
Original:  J:94203 Korets-Smith E, et al., Cre recombinase specificity defined by the tau locus. Genesis. 2004 Nov;40(3):131-8
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory