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Fkbp1atm1Slh
Targeted Allele Detail
Summary
Symbol: Fkbp1atm1Slh
Name: FK506 binding protein 1a; targeted mutation 1, Susan L Hamilton
MGI ID: MGI:3514012
Synonyms: Fkbp12Flox
Gene: Fkbp1a  Location: Chr2:151384403-151403611 bp, + strand  Genetic Position: Chr2, 74.83 cM
Alliance: Fkbp1atm1Slh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94747
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: The ES cell line used to create Fkbp1atm1Zuk (MGI:2158807)was modified so that a floxed neomycin resistance cassette could be found upstream of exon 3 and an additional loxP site was placed in the intron between exons 3 and 4. This involved the elimination of the hprt minigene in the original mutation and the restoration of exons 3 and 4. (J:94747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp1a Mutation:  14 strains or lines available
References
Original:  J:94747 Tang W, et al., Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency. FASEB J. 2004 Oct;18(13):1597-9
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory