Tg(Nkx2-5-cre)9Eno Transgene Detail MGI Mouse (MGI:3514028)

Tg(Nkx2-5-cre)9Eno
Transgene Detail

Summary

Symbol:	Tg(Nkx2-5-cre)9Eno
Name:	transgene insertion 9, Eric N Olson
MGI ID:	MGI:3514028
Synonyms:	Nk9, Nkx2.5-Cre, Nkx2.5::Cre, Nkx2.5Cre
Transgene:	Tg(Nkx2-5-cre)9Eno Location: unknown
Alliance:	Tg(Nkx2-5-cre)9Eno page

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 2 phenotype image(s) involving this allele.

Transgene
origin

Strain of Origin:

Not Specified

Transgene
description

Transgene Type:

Transgenic (Recombinase)

Mutation:

Insertion

Tg(Nkx2-5-cre)9Eno expression driven by 1 gene

Mutation details: A 2.5 kb fragment containing the mouse Nkx2.5 basal promoter and cardiac enhancer was placed in front of an NLS-cre cassette. Expression of cre is seen in developing heart, pharynx, and some liver cells. Three lines were created and line 9, which had the highest levels of cre recombination in the heart, was selected for use. (J:94514)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-5 (mouse) Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities Alliance mouse Nkx2-5 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

46 assay results
2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

Original:	J:94514 McFadden DG, et al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
All:	23 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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