Nt5e<tm1Lft> Targeted Allele Detail MGI Mouse (MGI:3522017)

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Nt5e^tm1Lft
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nt5e^tm1Lft
Name:	5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson
MGI ID:	MGI:3522017
Synonyms:	Cd73^-, CD73-KO
Gene:	Nt5e Location: Chr9:88209662-88254142 bp, + strand Genetic Position: Chr9, 47.24 cM, cytoband E3.2
Alliance:	Nt5e^tm1Lft page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:94697
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 3 was replaced with a neo cassette in reverse orientation to transcription. Northern blot of kidneys from mutant animlas indicated a lack of transcript. (J:94697)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Nt5e Mutation:	30 strains or lines available

References

Original:	J:94697 Thompson LF, et al., Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 6;200(11):1395-405
All:	95 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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