Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptpn11tm1Gsf
Name:	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Gen-Sheng Feng
MGI ID:	MGI:3522021
Synonyms:	Shp2f, Shp2flox, Shp2loxp
Gene:	Ptpn11  Location: Chr5:121268596-121329460 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Alliance:	Ptpn11tm1Gsf page

Germline Transmission:	Earliest citation of germline transmission: J:94738
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted to flank exon 4, which encodes amino acids 111-176. Deletion of the exon introduces a frameshift, creating a stop codon. (J:94738)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptpn11tm1Gsf

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:	46 strains or lines available

Original:	J:94738 Zhang EE, et al., Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16064-9
All:	79 reference(s)