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Cdh2tm1Glr
Targeted Allele Detail
Summary
Symbol: Cdh2tm1Glr
Name: cadherin 2; targeted mutation 1, Glenn L Radice
MGI ID: MGI:3522469
Synonyms: Ncadfl, N-cadflox
Gene: Cdh2  Location: Chr18:16721934-16942303 bp, - strand  Genetic Position: Chr18, 10.1 cM
Alliance: Cdh2tm1Glr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98828
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exon 1, which contains the translational start site and upstream transcriptional regulatory sequences, was flanked with loxP sites. An FRT-flanked neomycin selection cassette was inserted into intron 1 and subsequently removed by crossing with mice expressing FLP recombinase in the germline. (J:98828)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 147 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh2 Mutation:  51 strains or lines available
References
Original:  J:98828 Kostetskii I, et al., Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res. 2005 Feb 18;96(3):346-54
All:  59 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory