Btg2<tm1Spo> Targeted Allele Detail MGI Mouse (MGI:3525505)

Btg2^tm1Spo
Targeted Allele Detail

Summary

Symbol:	Btg2^tm1Spo
Name:	BTG anti-proliferation factor 2; targeted mutation 1, S Paul Oh
MGI ID:	MGI:3525505
Synonyms:	Btg2^-, PC3/Tis21^-
Gene:	Btg2 Location: Chr1:134002908-134006858 bp, - strand Genetic Position: Chr1, 58.1 cM
Alliance:	Btg2^tm1Spo page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95124
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance gene replaced exon 2, which contains sequence encoding APRO homology boxes A and B. Northern blot demonstrated the lack of transcript in mutant kidney samples. (J:95124)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Btg2^tm1Spo

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Btg2 Mutation:	16 strains or lines available

References

Original:	J:95124 Park S, et al., B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol. 2004 Dec;24(23):10256-62
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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