Sphk1<tm1Rlp> Targeted Allele Detail MGI Mouse (MGI:3526071)

Sphk1^tm1Rlp
Targeted Allele Detail

Summary

Symbol:	Sphk1^tm1Rlp
Name:	sphingosine kinase 1; targeted mutation 1, Richard L Proia
MGI ID:	MGI:3526071
Synonyms:	SK1^-, Sphk1^-, SphK1 KO
Gene:	Sphk1 Location: Chr11:116421751-116427501 bp, + strand Genetic Position: Chr11, 81.42 cM, cytoband E2
Alliance:	Sphk1^tm1Rlp page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95168
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neo replaced exons 3-5 and the 5' end of exon 6, deleting sequence corresponding to the putative lipid kinase catalytic domain, which contains the conserved domains C1, C2, C3 and part of C4, and a putative nucleotide binding motif. Absence of mRNA was demonstrated in kidney samples by Northern blot and RT-PCR analyses. (J:95168)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Sphk1^tm1Rlp

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:	29 strains or lines available

References

Original:	J:95168 Allende ML, et al., Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 2004 Dec 10;279(50):52487-92
All:	99 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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