Zap70<st> Spontaneous Allele Detail MGI Mouse (MGI:3526403)

Zap70^st
Spontaneous Allele Detail

Summary

Symbol:	Zap70^st
Name:	zeta-chain (TCR) associated protein kinase; strange
MGI ID:	MGI:3526403
Gene:	Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70^st page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: RT-PCR and sequence analysis revealed eight nucleotide differences relative to wild-type sequence. Seven were silent and one, a C-to-T transition, caused an arginine to cystein change at position 464 (p.R464C), thereby disrupting the conserved DLAARN motif within the kinase domain. (J:41170)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

References

Original:	J:41170 Wiest DL, et al., A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997 Jun;6(6):663-71
All:	2 reference(s)

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