Homer2<tm1Mhd> Targeted Allele Detail MGI Mouse (MGI:3526530)

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Homer2^tm1Mhd
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Homer2^tm1Mhd
Name:	homer scaffolding protein 2; targeted mutation 1, Marlin H Dehoff
MGI ID:	MGI:3526530
Synonyms:	H2ko
Gene:	Homer2 Location: Chr7:81250229-81356673 bp, - strand Genetic Position: Chr7, 45.71 cM
Alliance:	Homer2^tm1Mhd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95213
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A PGK-neomycin gene was inserted in inverse orientation into exon 3. mRNA and protein products could not be detected. (J:95213)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Homer2 Mutation:	22 strains or lines available

References

Original:	J:95213 Shin DM, et al., Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol. 2003 Jul 21;162(2):293-303
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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