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Abi2tm1Pen
Targeted Allele Detail
Summary
Symbol: Abi2tm1Pen
Name: abl interactor 2; targeted mutation 1, Ann Marie Pendergast
MGI ID: MGI:3526871
Synonyms: Abi2-
Gene: Abi2  Location: Chr1:60448778-60520317 bp, + strand  Genetic Position: Chr1, 30.47 cM
Alliance: Abi2tm1Pen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95254
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A targeting vector was designed to replace exons 2 and 3 with a PGK-neo. Immunoblot of MEFs or brains from mutants demonstrated a lack of protein. (J:95254)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abi2 Mutation:  40 strains or lines available
References
Original:  J:95254 Grove M, et al., ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol. 2004 Dec;24(24):10905-22
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory