Tlr1<tm1Flv> Targeted Allele Detail MGI Mouse (MGI:3526882)

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Tlr1^tm1Flv
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Tlr1^tm1Flv
Name:	toll-like receptor 1; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:3526882
Synonyms:	TLR1^-
Gene:	Tlr1 Location: Chr5:65082022-65090906 bp, - strand Genetic Position: Chr5, 33.53 cM
Alliance:	Tlr1^tm1Flv page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95726
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Disruption caused by insertion of vector
		Mutation details: The entire gene was replaced by a neomycin resistance cassette. Rt-PCR confirmed the absence of transcription. (J:95726)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tlr1 Mutation:	52 strains or lines available

References

Original:	J:95726 Alexopoulou L, et al., Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002 Aug;8(8):878-84
All:	3 reference(s)

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