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Map2k5tm1Ctr
Targeted Allele Detail
Summary
Symbol: Map2k5tm1Ctr
Name: mitogen-activated protein kinase kinase 5; targeted mutation 1, Cathy Tournier
MGI ID: MGI:3526901
Synonyms: mek5-
Gene: Map2k5  Location: Chr9:63071050-63285184 bp, - strand  Genetic Position: Chr9, 33.96 cM
Alliance: Map2k5tm1Ctr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95388
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: Exon 2 was interrupted with the insertion of a lacZ-neo cassette in frame. Staining demonstrated Beta-galactosidase expression was ubiquitous. (J:95388)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k5 Mutation:  38 strains or lines available
References
Original:  J:95388 Wang X, et al., Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol. 2005 Jan;25(1):336-45
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory