Drd1tm2Rpa
Targeted Allele Detail
|
|
| Symbol: |
Drd1tm2Rpa |
| Name: |
dopamine receptor D1; targeted mutation 1, Richard D Palmiter |
| MGI ID: |
MGI:3527157 |
| Synonyms: |
D1R-NR1m, Drd1adnNR1, Drd1aGrin1-N616R |
| Gene: |
Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
|
| Alliance: |
Drd1tm2Rpa page
|
|
|
|
| Allele Type: |
|
Targeted (Dominant negative) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: A cDNA open reading frame encoding a dominant-negative mutant NR1 subunit of the NMDA receptor with an asparagine-to-arginine substitution at amino acid 616 (N616R), a hemagglutinin (HA) epitope tag 27 aa from the N terminus and a polyadenylation signal, followed by a loxP-flanked SV40-neo cassette, has replaced the first ~130 base pairs of the endogenous Drd1a gene.
(J:121750)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Original: |
J:121750 Heusner CL, et al., Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. J Neurosci. 2005 Jul 13;25(28):6651-7 |
| All: |
2 reference(s) |
|
Analysis Tools
