Adgrv1<tm1Msat> Targeted Allele Detail MGI Mouse (MGI:3527179)

Adgrv1^tm1Msat
Targeted Allele Detail

Summary

Symbol:	Adgrv1^tm1Msat
Name:	adhesion G protein-coupled receptor V1; targeted mutation 1, Makoto Sato
MGI ID:	MGI:3527179
Synonyms:	Vlgr1^-
Gene:	Adgrv1 Location: Chr13:81243187-81781273 bp, - strand Genetic Position: Chr13, 42.18 cM
Alliance:	Adgrv1^tm1Msat page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95518
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance gene replaced exons 2-4. RT-PCR showed that transcripts from mutant animals lacked these exons, and that exon 1 was ligated to exon 5. A stop codon was created by frame shifting in the resulting truncated mRNA transcribed from the direct connection of exon 1 to exon 5, and would result in a 14 amino acid peptide, if any. (J:95518)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Adgrv1 Mutation:	318 strains or lines available

References

Original:	J:95518 Yagi H, et al., Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202
All:	7 reference(s)

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