Akr1c18tm1Jni
Targeted Allele Detail
|
|
| Symbol: |
Akr1c18tm1Jni |
| Name: |
aldo-keto reductase family 1, member C18; targeted mutation 1, James N Ihle |
| MGI ID: |
MGI:3527218 |
| Synonyms: |
20alpha-HSD- |
| Gene: |
Akr1c18 Location: Chr13:4182614-4200645 bp, - strand Genetic Position: Chr13, 2.31 cM
|
| Alliance: |
Akr1c18tm1Jni page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:95560
|
| Parent Cell Line: |
E14 (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: Exons 2 and 3, encoding essential components of the enzyme's active site, were replaced with a neo in reverse transcription orientation. Western blot of mutant adrenal, kidney and ovary confirmed the lack of protein.
(J:95560)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Akr1c18 Mutation: |
29 strains or lines available
|
|
| Original: |
J:95560 Piekorz RP, et al., Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol. 2005 Feb;19(2):431-40 |
| All: |
2 reference(s) |
|
Analysis Tools
