Rad50tm1Flv
Targeted Allele Detail
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| Symbol: |
Rad50tm1Flv |
| Name: |
RAD50 double strand break repair protein; targeted mutation 1, Richard A Flavell |
| MGI ID: |
MGI:3527268 |
| Synonyms: |
RHS7-deficient |
| Gene: |
Rad50 Location: Chr11:53540346-53598146 bp, - strand Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
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| Alliance: |
Rad50tm1Flv page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:94870
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted |
| Mutation: |
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Intragenic deletion
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Mutation details: The RHS7 site (Rad50 hypersensitive site 7), a 637 bp region located in intron 24, was replaced with a floxed neomycin resistance cassette. The resistance cassette was subsequently removed from the ES cells by transient cre expression. There was no effect on Rad50 expression.
(J:94870)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rad50 Mutation: |
53 strains or lines available
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RHS7 makes up one component of a locus control region for TH2 cytokines.
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| Original: |
J:94870 Lee GR, et al., Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol. 2005 Jan;6(1):42-8 |
| All: |
4 reference(s) |
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Analysis Tools
