Atp1a1<tm2Ling> Targeted Allele Detail MGI Mouse (MGI:3527337)

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Atp1a1^tm2Ling
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Atp1a1^tm2Ling
Name:	ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 2, Jerry B Lingrel
MGI ID:	MGI:3527337
Synonyms:	alpha1^S
Gene:	Atp1a1 Location: Chr3:101483535-101512000 bp, - strand Genetic Position: Chr3, 44.3 cM, cytoband F3
Alliance:	Atp1a1^tm2Ling page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95157
Parent Cell Line:	Duffy (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted
Mutation:		Nucleotide substitutions
		Mutation details: Two point mutations were introduced into the first extracellular domain of exon 4: R111Q and D122N. Western blot showed that protein expression was normal. (J:95157)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Atp1a1 Mutation:	61 strains or lines available

References

Original:	J:95157 Dostanic I, et al., The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem. 2004 Dec 24;279(52):54053-61
All:	13 reference(s)

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