Cngb1<tm1.1Biel> Targeted Allele Detail MGI Mouse (MGI:3527896)

Cngb1^tm1.1Biel
Targeted Allele Detail

Summary

Symbol:	Cngb1^tm1.1Biel
Name:	cyclic nucleotide gated channel beta 1; targeted mutation 1.1, Martin Biel
MGI ID:	MGI:3527896
Synonyms:	GNGB1^-
Gene:	Cngb1 Location: Chr8:95965673-96033213 bp, - strand Genetic Position: Chr8, 47.12 cM
Alliance:	Cngb1^tm1.1Biel page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:95768
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exon 26 was removed via Cre-mediated excision, leaving a single loxP site. RT-PCR analysis demonstrated no transcript was present in mutant retinas and Western blot using an antibody against the C terminus showed the lack of protein in mutants. (J:95768)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cngb1 Mutation:	61 strains or lines available

References

Original:	J:95768 Huttl S, et al., Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci. 2005 Jan 5;25(1):130-8
All:	13 reference(s)

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