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Tg(Prnp-SNCA)22Dpr
Transgene Detail
Summary
Symbol: Tg(Prnp-SNCA)22Dpr
Name: transgene insertion 22, Donald L Price
MGI ID: MGI:3530087
Synonyms: Hualpha-Syn(WT), I2-2, MoPrP-Hualpha-Syn(WT)
Transgene: Tg(Prnp-SNCA)22Dpr  Location: unknown  
Alliance: Tg(Prnp-SNCA)22Dpr page
Transgene
origin
Strain of Origin:  (C3H/HeJ x C57BL/6J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-SNCA)22Dpr expresses 1 gene
    The transgene contains a wild-type human alpha synuclein cDNA and the murine prion promoter. (J:77344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
This line was originally designated I2-2. Transgenic mice express high levels of the human protein in the brain, but do not develop neurological abnormalities at any age. These mice do not show obvious abnormal accumulation of human alpha synuclein or ubiquitin.
References
Original:  J:77344 Lee MK, et al., Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory