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Suz12Gt(Betageo)1Khe
Gene trapped Allele Detail
Summary
Symbol: Suz12Gt(Betageo)1Khe
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap 1, Kristian Helin
MGI ID: MGI:3530650
Synonyms: Suz12-, Suz12502gt, Suz12Gt(XG122)Byg
Gene: Suz12  Location: Chr11:79883932-79924949 bp, + strand  Genetic Position: Chr11, 47.36 cM
Alliance: Suz12Gt(Betageo)1Khe page
Mutation
origin
Mutant Cell Line:  XG122
Germline Transmission:  Earliest citation of germline transmission: J:93307
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA gene trap vector inserted into intron 7 which created a truncation containing 276 N-terminal amino acids fused to 1323 amino acids of the Betagalactosidase-neo protein. The translated protein was functionally inactive. (J:93307)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Suz12 Mutation:  61 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:93307 Pasini D, et al., Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004 Nov 13;23(20):4061-71
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory