About   Help   FAQ
Suz12Gt(Betageo)1Khe
Gene trapped Allele Detail
Summary
Symbol: Suz12Gt(Betageo)1Khe
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap 1, Kristian Helin
MGI ID: MGI:3530650
Synonyms: Suz12-, Suz12502gt, Suz12Gt(XG122)Byg
Gene: Suz12  Location: Chr11:79883932-79924949 bp, + strand  Genetic Position: Chr11, 47.36 cM
Alliance: Suz12Gt(Betageo)1Khe page
Mutation
origin
Mutant Cell Line:  XG122
Germline Transmission:  Earliest citation of germline transmission: J:93307
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation details: A gene trap vector inserted into intron 7 which created a truncation containing 276 N-terminal amino acids fused to 1323 amino acids of the Betagalactosidase-neo protein. The translated protein was functionally inactive. (J:93307)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Suz12 Mutation:  61 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:93307 Pasini D, et al., Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004 Nov 13;23(20):4061-71
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory