Phox2a/Inppl1<tm1Ssch> Targeted Allele Detail MGI Mouse (MGI:3531322)

Phox2a/Inppl1^tm1Ssch
Targeted Allele Detail

Summary

Symbol:	Phox2a/Inppl1^tm1Ssch
Name:	inositol polyphosphate phosphatase-like 1; targeted mutation 1, Stephane Schurmans
MGI ID:	MGI:3531322
Synonyms:	SHIP2^-
Gene:	Inppl1 Location: Chr7:101471839-101487419 bp, - strand Genetic Position: Chr7, 54.67 cM, cytoband F1
Alliance:	Phox2a/Inppl1^tm1Ssch page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:96443
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intergenic deletion
		Mutation details: 7.3 kb genomic sequence containing C-terminal of two genes, Inppl1 and Phox2a were disrupted by the integration of a single targeting construct. A neomycin selection cassette replaced sequence extending from Inppl1 (exons 19-29) and Phox2a (exon 3). (J:96443)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Inppl1 Mutation:	45 strains or lines available

References

Original:	J:96443 Clement S, et al., The lipid phosphatase SHIP2 controls insulin sensitivity. (Erratum: Nature 2004 Oct 14;4131(7010):878). Nature. 2001 Jan 4;409(6816):92-7
All:	1 reference(s)

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