Cd36<obl> Chemically induced Allele Detail MGI Mouse (MGI:3573941)

Cd36^obl
Chemically induced Allele Detail

Summary

Symbol:	Cd36^obl
Name:	CD36 molecule; oblivious
MGI ID:	MGI:3573941
Synonyms:	Cd36^m1Btlr, obl
Gene:	Cd36 Location: Chr5:17986688-18093799 bp, - strand Genetic Position: Chr5, 8.11 cM
Alliance:	Cd36^obl page

Mutation
origin

Strain of Origin:

C57BL/6

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: This allele contains a T to A point mutation at position 1022 in exon 11, creating an early stop codon and removing 133 residues from the C-terminus of the polypeptide chain. Loss of these amino acids prevented formation of the second of two transmembrain domains. Western blot against antibodies for the amino terminal showed an absence of protein in whole cell extracts and supernatant. (J:96018)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cd36 Mutation:	34 strains or lines available

References

Original:	J:96018 Hoebe K, et al., CD36 is a sensor of diacylglycerides. Nature. 2005 Feb 3;433(7025):523-7
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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