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Tg(SOD1*G37R)29Dpr
Transgene Detail
Summary
Symbol: Tg(SOD1*G37R)29Dpr
Name: transgene insertion 29, Donald L Price
MGI ID: MGI:3574016
Synonyms: G37R SOD1 (line 29), Tg(SOD1-G37R)29Dpr
Transgene: Tg(SOD1*G37R)29Dpr  Location: unknown  
Alliance: Tg(SOD1*G37R)29Dpr page
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SOD1*G37R)29Dpr expresses 1 gene
 
Mutation details: A 12 kb genomic DNA fragment containing a mutated form of human SOD1 with a glycine to arginine substitution at amino acid 37 (G37R) was used for the transgene. The G37R mutation is found in some cases of familial amyotrophic lateral sclerosis (FALS). (J:69178)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
cx1
Tg(NEFH)200Jpj/0
Tg(SOD1*G37R)29Dpr/0
involves: C3H/HeJ * C57BL/6 * C57BL/6J
 
cx2
Tg(NEFH)398Jpj/0
Tg(SOD1*G37R)29Dpr/0
involves: C3H/HeJ * C57BL/6 * C57BL/6J
 
tg3
Tg(SOD1*G37R)29Dpr/0
involves: C3H/HeJ * C57BL/6 * C57BL/6J
 
tg4  Disease Model
Tg(SOD1*G37R)29Dpr/0
involves: C3H/HeJ * C57BL/6J
 
Phenotypes:
Affected Systems
cx1
cx2
tg3
tg4
show or hide all annotated terms
       
behavior/neurological
√ √
tremors
√
weakness
√
decreased locomotor activity
√
paralysis
√
hindlimb paralysis
√
cellular
√
abnormal motor neuron mitochondrial morphology
√
growth/size/body
√ √
weight loss
√ √
homeostasis/metabolism
√
abnormal iron homeostasis
√
abnormal iron level
√
integument
√
rough coat
√
mortality/aging
√ √ √
premature death
√ √ √
muscle
√
muscular atrophy
√
abnormal muscle electrophysiology
√
nervous system
√ √ √ √
abnormal neuron morphology
√
abnormal motor neuron mitochondrial morphology
√
decreased motor neuron number
√
motor neuron degeneration
√ √ √ √
decreased sensory neuron number
√ √ √
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
√ disease model   expected model not found
Models:
Human Diseases
tg4
IDs
 √
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:69178 Wong PC, et al., An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 Jun;14(6):1105-16
All:  42 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory
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