Hey2<tm1Kkb> Targeted Allele Detail MGI Mouse (MGI:3574394)

Hey2^tm1Kkb
Targeted Allele Detail

Summary

Symbol:	Hey2^tm1Kkb
Name:	hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Hiroki Kokubo
MGI ID:	MGI:3574394
Synonyms:	hesr2^-
Gene:	Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
Alliance:	Hey2^tm1Kkb page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:97120
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: A targeting construct was designed to delete the entire coding region by replacing it with a loxP neo cassette subsequently removed via cre mediated excision. (J:97120)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hey2 Mutation:	31 strains or lines available

References

Original:	J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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