Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:3576373
Synonyms:	Gt(ROSA)26Sortm1(smo/YFP)Amc, R26-lsl-SmoM2, R26SmoM2, R26SmoM2, RosaSmoM2 c, SmoM2, SmoM2fl, SmoM2/Yfp, SmoM2-YFPfl, SmoOEX
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Smo/EYFP)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:89445
Parent Cell Line:	AV3 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1(Smo/EYFP)Amc expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Smo (MGI:108075)   Mutation details: A loxP flanked PGK-neo-stop cassette upstream of the Yellow Fluorescent Protein (YFP) and mouse gene (SMO/EYFP) was inserted into the locus. The mutant allele consists of a fusion product involving YFP and the constitutively active W539L point mutation of the mouse gene (SmoM2), which corresponds to the W535L mutation in the human sequence. Expression of the fusion gene is blocked by a loxP-flanked STOP fragment placed between the endogenous promoter and the fusion sequence. (J:89445)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(Smo/EYFP)Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	994 strains or lines available

Original:	J:89445 Jeong J, et al., Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51
All:	186 reference(s)