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Drd2tm1Mok
Targeted Allele Detail
Summary
Symbol: Drd2tm1Mok
Name: dopamine receptor D2; targeted mutation 1, Motoya Katsuki
MGI ID: MGI:3576789
Synonyms: D2KO
Gene: Drd2  Location: Chr9:49251927-49319477 bp, + strand  Genetic Position: Chr9, 26.72 cM
Alliance: Drd2tm1Mok page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97838
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
hm1
Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv
 
hm2
Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J
 
Phenotypes:
Affected Systems
hm1
hm2
show or hide all annotated terms
   
endocrine/exocrine glands
√
enlarged pituitary intermediate lobe
√
homeostasis/metabolism
√
abnormal circulating hormone level
√
increased pituitary hormone level
√
integument
√
darkened coat color
√
nervous system
√ √
enlarged pituitary intermediate lobe
√
abnormal single cell response
√ √
pigmentation
√
darkened coat color
√
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 19 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  70 strains or lines available
References
Original:  J:97838 Yamaguchi H, et al., Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory