Drd2<tm1Mok> Targeted Allele Detail MGI Mouse (MGI:3576789)

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Drd2^tm1Mok
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Drd2^tm1Mok
Name:	dopamine receptor D2; targeted mutation 1, Motoya Katsuki
MGI ID:	MGI:3576789
Synonyms:	D2KO
Gene:	Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
Alliance:	Drd2^tm1Mok page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:97838
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 19 strains available Cell Lines: 0 lines available
Carrying any Drd2 Mutation:	70 strains or lines available

References

Original:	J:97838 Yamaguchi H, et al., Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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