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Myh11tm1Peri
Targeted Allele Detail
Summary
Symbol: Myh11tm1Peri
Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1, Muthu Periasamy
MGI ID: MGI:3576856
Synonyms: smb-
Gene: Myh11  Location: Chr16:14012392-14109227 bp, - strand  Genetic Position: Chr16, 9.71 cM
Alliance: Myh11tm1Peri page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97927
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 5b was replaced with a PGK-neo cassette. RNase protection and Western blot confirmed successful ablation of the SM-B isoform. (J:97927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:  94 strains or lines available
References
Original:  J:97927 Babu GJ, et al., Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol. 2001 Nov;3(11):1025-9
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory