Kif20b<33cex> Chemically induced Allele Detail MGI Mouse (MGI:3578531)

Kif20b^33cex
Chemically induced Allele Detail

Summary

Symbol:	Kif20b^33cex
Name:	kinesin family member 20B; 33c exencephaly
MGI ID:	MGI:3578531
Synonyms:	33C, mcbarker
Gene:	Kif20b Location: Chr19:34899761-34953145 bp, + strand Genetic Position: Chr19, 29.79 cM
Alliance:	Kif20b^33cex page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: ENU mutagenesis induced an A-to-G mutation, leading to a missense mutation that changes arginine residue 397 to glycine (p.R397G) in loop 11 of the motor head domain of the encoded peptide. (J:205043)
Inheritance:		Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background
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hm1	Kif20b^33cex/Kif20b^33cex	involves: C3HeB/FeJ * C57BL/6J
ht2	Kif20b^33cex/Kif20b^magoo	involves: BALB/c * C3HeB/FeJ * C57BL/6 * FVB/N

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
growth/size/body		√
abnormal head morphology		√
microcephaly		√
mortality/aging	√
embryonic lethality during organogenesis, complete penetrance	√
nervous system	√	√
abnormal brain morphology	√
abnormal forebrain morphology		√
decreased forebrain size		√
exencephaly	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Kif20b Mutation:	69 strains or lines available

References

Original:	J:98216 Garcia-Garcia MJ, et al., Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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