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Itgad Gene Detail
Summary
  • Symbol
    Itgad
  • Name
    integrin, alpha D
  • Synonyms
    Cd11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:3578624
    NCBI Gene: 381924
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127773105-127822988 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3578624
 protein coding gene Chr7:127753548-127822988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033074
 protein coding gene Chr7:132560558-132629889 (+)
A/J MGP_AJ_G0033056
 protein coding gene Chr7:128995793-129067858 (+)
AKR/J MGP_AKRJ_G0032988
 protein coding gene Chr7:132357957-132444978 (+)
BALB/cJ MGP_BALBcJ_G0033057
 protein coding gene Chr7:128659700-128732696 (+)
C3H/HeJ MGP_C3HHeJ_G0032771
 protein coding gene Chr7:132255734-132329071 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033567
 protein coding gene Chr7:137721684-137804624 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030539
 protein coding gene Chr7:130184214-130231983 (+)
CAST/EiJ MGP_CASTEiJ_G0032101
 protein coding gene Chr7:124043765-124118904 (+)
CBA/J MGP_CBAJ_G0032744
 protein coding gene Chr7:142419946-142502135 (+)
DBA/2J MGP_DBA2J_G0032896
 protein coding gene Chr7:126986368-127057637 (+)
FVB/NJ MGP_FVBNJ_G0032849
 protein coding gene Chr7:126846282-126916354 (+)
LP/J MGP_LPJ_G0032990
 protein coding gene Chr7:134036447-134109900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032881
 protein coding gene Chr7:143469165-143539428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033586
 protein coding gene Chr7:131333769-131406831 (+)
PWK/PhJ MGP_PWKPhJ_G0031807
 protein coding gene Chr7:119987021-120065452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031653
 protein coding gene Chr7:118131332-118210299 (+)
WSB/EiJ MGP_WSBEiJ_G0032212
 protein coding gene Chr7:132304301-132385272 (+)



Homology
more
  • Human Ortholog
    ITGAD, integrin subunit alpha D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAD, integrin subunit alpha D
  • Synonyms
    ADB2, CD11D
  • Links
    NCBI Gene ID: 3681
    neXtProt AC: NX_Q13349
    UniProt: Q13349

  • Chr Location
    16p11.2; chr16:31393335-31426505 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced staphylococcal enterotoxin-induced T cell response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381924 NCBI Gene Model | MGI Sequence Detail 49884 C57BL/6J ±  kb
    transcript NM_001029872 RefSeq | MGI Sequence Detail 3975 C57BL/6  
    polypeptide Q3V0T4 UniProt | EBI | MGI Sequence Detail 1168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000001009 integrin alpha-D
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048633 Integrin alpha-X-like, third Ig-like domain
      IPR032695 Integrin domain superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      Q3V0T4 11 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
    • Latest
      J:347839 Hou L, et al., CD11a regulates hematopoietic stem and progenitor cells. Front Immunol. 2023;14:1219953
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory