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Plxna4tm1Hfu
Targeted Allele Detail
Summary
Symbol: Plxna4tm1Hfu
Name: plexin A4; targeted mutation 1, Hajime Fujisawa
MGI ID: MGI:3578655
Synonyms: PlxnA4-
Gene: Plxna4  Location: Chr6:32121478-32565127 bp, - strand  Genetic Position: Chr6, 12.9 cM, cytoband B1
Alliance: Plxna4tm1Hfu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98330
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Most of the exon, including the coding region for the sema domain, was deleted upon the insertion of a loxP-IRES Tak PGK-neo cassette. Western blot confirmed that mutants have the null allele. (J:98330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plxna4 Mutation:  99 strains or lines available
References
Original:  J:98330 Suto F, et al., Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci. 2005 Apr 6;25(14):3628-37
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory