Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Stk11tm1Keis Name: serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto MGI ID: MGI:3579498 Synonyms: LKB1fl, Lkb1hypo Gene: Stk11  Location: Chr10:79951637-79966516 bp, + strand  Genetic Position: Chr10, 39.72 cM Alliance: Stk11tm1Keis page

Urothelial hyperplasia and increased apoptosis in bladder epithelium of Ptentm2Mak/Ptentm2Mak Stk11tm1Keis/Stk11tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:98513
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Stk11tm1Keis

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:	35 strains or lines available

Original:	J:98513 Sakamoto K, et al., Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 2005 May 18;24(10):1810-20
All:	26 reference(s)