Sphk2<Gt(NPX039)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3580701)

Sphk2^{Gt(NPX039)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Sphk2^{Gt(NPX039)Byg}
Name:	sphingosine kinase 2; gene trap NPX039, BayGenomics
MGI ID:	MGI:3580701
Synonyms:	Sphk2^{Gt(pGT1dTMpfs)1Kly}
Gene:	Sphk2 Location: Chr7:45358891-45367426 bp, - strand Genetic Position: Chr7, 29.45 cM
Alliance:	Sphk2^{Gt(NPX039)Byg} page

Mutation
origin

Mutant Cell Line:	NPX039
Germline Transmission:	Earliest citation of germline transmission: J:102911
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1dTMpfs Vector Type: secretory trap

Mutation details: BayGenomics exon trap vector: pGT1dTMpfs (11611 nt). The trap element inserted 1.7 kbp downstream of the second exon. RT-PCR did not detect mRNA in kidney. (J:102911)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Sphk2 Mutation:	38 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:102911 Kharel Y, et al., Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem. 2005 Nov 4;280(44):36865-72
All:	4 reference(s)

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