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Spint1tm1Hk
Targeted Allele Detail
Summary
Symbol: Spint1tm1Hk
Name: serine protease inhibitor, Kunitz type 1; targeted mutation 1, Hiroaki Kataoka
MGI ID: MGI:3581891
Synonyms: HAI-1-
Gene: Spint1  Location: Chr2:119067841-119079995 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E5
Alliance: Spint1tm1Hk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99182
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exons 5-11, which correspond to the first Kunitz domain, the LDL receptor class A domain, the second Kunitz domain, the transmembrane domain and the intracytoplasmic domain. RT-PCR of mutant embryos confirmed absence of transcript. (J:99182)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spint1 Mutation:  26 strains or lines available
References
Original:  J:99182 Tanaka H, et al., Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Is Required for Branching Morphogenesis in the Chorioallantoic Placenta. Mol Cell Biol. 2005 Jul;25(13):5687-98
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory