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Thbs3tm1Bst
Targeted Allele Detail
Summary
Symbol: Thbs3tm1Bst
Name: thrombospondin 3; targeted mutation 1, Paul Bornstein
MGI ID: MGI:3581964
Synonyms: Thbs3-
Gene: Thbs3  Location: Chr3:89122487-89134144 bp, + strand  Genetic Position: Chr3, 39.01 cM, cytoband E3-F1
Alliance: Thbs3tm1Bst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99120
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A PGK-neo flanked by loxP sites was inserted into exon B, incorporating an in-frame stop codon upstream from the cassette. Northern blot of RNA from mutant lungs confirmed creation of a null allele.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbs3 Mutation:  50 strains or lines available
References
Original:  J:99120 Hankenson KD, et al., Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol. 2005 Jul;25(13):5599-606
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory