Fcer2a<tm1Kik> Targeted Allele Detail MGI Mouse (MGI:3583003)

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Fcer2a^tm1Kik
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Fcer2a^tm1Kik
Name:	Fc receptor, IgE, low affinity II, alpha polypeptide; targeted mutation 1, Hitoshi Kikutani
MGI ID:	MGI:3583003
Synonyms:	CD23^-
Gene:	Fcer2a Location: Chr8:3731737-3744175 bp, - strand Genetic Position: Chr8, 1.92 cM, cytoband A1
Alliance:	Fcer2a^tm1Kik page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:19437
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance cassette was inserted into exon 4. Northern blot of mutant lymphocytes confirmed absence of transcript. (J:19437)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Fcer2a Mutation:	24 strains or lines available

References

Original:	J:19437 Fujiwara H, et al., The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6835-9
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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