Rrn3tm1.2Igt
Targeted Allele Detail
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| Symbol: |
Rrn3tm1.2Igt |
| Name: |
RRN3 RNA polymerase I transcription factor homolog (yeast); targeted mutation 1.2, Ingrid Grummt |
| MGI ID: |
MGI:3584037 |
| Synonyms: |
TIF-1A- |
| Gene: |
Rrn3 Location: Chr16:13598572-13632703 bp, + strand Genetic Position: Chr16, 9.59 cM
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| Alliance: |
Rrn3tm1.2Igt page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:99711
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129/Sv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: An FRP-flanked neomycin resistance cassette downstream of a loxP site was inserted into intron 11 and a second loxP site was inserted in to intron 14 via homologous recombination. Heterozygous mice were bred with Tg(CMV-cre)1Cgn carriers to excise exons 12-14. RT-PCR analysis indicated that no detectable transcript was expressed from this allele.
(J:99711)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rrn3 Mutation: |
42 strains or lines available
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| Original: |
J:99711 Yuan X, et al., Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell. 2005 Jul 1;19(1):77-87 |
| All: |
2 reference(s) |
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Analysis Tools
