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Fxyd2tm1Kdr
Targeted Allele Detail
Summary
Symbol: Fxyd2tm1Kdr
Name: FXYD domain-containing ion transport regulator 2; targeted mutation 1, Gerald M Kidder
MGI ID: MGI:3586329
Synonyms: Fxyd2-
Gene: Fxyd2  Location: Chr9:45311007-45321576 bp, + strand  Genetic Position: Chr9, 24.84 cM, cytoband B
Alliance: Fxyd2tm1Kdr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99929
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Most of exon 4, encoding most of the transmembrane domain, was replaced with a neomycin resistance gene and a lacZ gene. Absense of gamma subunits in mutants was confirmed by Western blot. (J:99929)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fxyd2 Mutation:  13 strains or lines available
References
Original:  J:99929 Jones DH, et al., Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13;280(19):19003-11
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory