About   Help   FAQ
Fxyd2tm1Kdr
Targeted Allele Detail
Summary
Symbol: Fxyd2tm1Kdr
Name: FXYD domain-containing ion transport regulator 2; targeted mutation 1, Gerald M Kidder
MGI ID: MGI:3586329
Synonyms: Fxyd2-
Gene: Fxyd2  Location: Chr9:45311007-45321576 bp, + strand  Genetic Position: Chr9, 24.84 cM, cytoband B
Alliance: Fxyd2tm1Kdr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99929
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Most of exon 4, encoding most of the transmembrane domain, was replaced with a neomycin resistance gene and a lacZ gene. Absense of gamma subunits in mutants was confirmed by Western blot. (J:99929)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fxyd2 Mutation:  13 strains or lines available
References
Original:  J:99929 Jones DH, et al., Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13;280(19):19003-11
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory